Coronary Artery Disease (CAD) remains the leading cause of death worldwide. With progress made in treatment, an increasing number of patients survive acute coronary syndromes and live as outpatients with or without anginal symptoms.

Data available today on presentation and management of these outpatients with stable CAD come mainly from clinical trials or registries which often have stringent exclusion criteria, and thus do not adequately represent populations with stable CAD (in terms of age, comorbidity, and concomitant therapy).

Moreover, in spite of extensive evidence of the importance of heart rate (HR) in the prognosis of stable CAD3, HR is not yet a routine component of cardiovascular risk assessment, or in deciding whether treatment is indicated. We also lack data on the HRs actually achieved in practice, and their prognostic value.

Improving understanding of the management and outcomes of these patients with stable CAD is paramount for reducing the CAD disease burden.

Thus, the rationale of this new international Registry is both:

  • A need for worldwide contemporary data in stable CAD outpatients to generalize the finding from randomized clinical trials and most registries in CAD that is often limiting.
  • A need to obtain determinants of long-term prognosis, including heart rate in outpatients with stable CAD to analyze not only the baseline characteristics and management practices but also outcomes and prognostic determinants.

References:

1. The GRACE Investigators. Rationale and design of the GRACE (Global Registry of Acute Coronary Events) project: a multinational registry of patients hospitalized with acute coronary syndromes. Am Heart J. 2001;141:190-199.
2. Daly CA, Clemens F, Sendon JL et al. The clinical characteristics and investigations planned in patients with stable angina presenting to cardiologists in Europe: from the Euro Heart Survey of Stable Angina.Euro Heart Survey Investigators. Eur Heart J. 2005;26(10):996-1010.
3. Fox K et al. Heart rate as a prognostic risk factor in patients with coronary artery disease and left ventricular systolic dysfunction. Lancet. 2008;372:817-821.