Recent results from CLARIFY, presented by Professor Jean-Claude Tardif at the European Society of Cardiology Congress 2012 in Munich, reveal the existence of major age-related differences in the characteristics, treatment and outcome of patients with stable coronary artery disease (CAD).

CLARIFY (ProspeCtive observational LongitudinAl RegIstry oF patients with stable coronary arterY disease) is the largest international registry in stable CAD outpatients. CLARIFY is ongoing in 45 countries in Europe, the Americas, Africa, the Middle East, and the Asia/Pacific region. 33 285 patients were enrolled between November 2009 and July 2010 and will be followed up annually for 5 years.

The current analysis assessed age-specific differences in clinical characteristics, treatments and in 1-year outcomes in patients enrolled in the CLARIFY registry. 30 978 patients with age recorded and having had their first annual visit, or died or withdrew up to the first annual visit were included in this analysis. Patients were divided into 3 age groups: below 65 years (n=16 068), 65-74 years (n=10 128), and 75 years and above (n=4782).

Compared with those <65 years, older patients had higher systolic blood pressure, lower body mass index and more often comorbidities such as hypertension, peripheral artery disease, asthma or chronic obstructive pulmonary disease. Elderly patients received fewer cardiovascular medications, including beta-blockers. Elderly patients had a worse prognosis with a markedly higher rate of 1-year all-cause and cardiovascular death (Figure).